MoA Technology has three innovative herbicide discovery platforms based on an in vivo plant model designed to pinpoint and elucidate new modes of action, essential to developing safe and effective active ingredients to control weeds.
The platforms need only sub-microgram test samples, ideal for screening chemical libraries not previously screened by conventional methods requiring high quantities, or those from which traditional high-throughput screening failed to detect hits.
Each molecule tested generates a data-rich ‘fingerprint’. Artificial intelligence systems pick out hits with novel modes of action.
Used together in sequence, MoA platforms can quickly and cost-effectively find streams of herbicidally active chemicals structurally unrelated to the original hits and having the newly defined mode of action.
At MoA Technology our ambition is to discover the next generation of sustainable herbicide chemistries with new modes of action from both natural and synthetic sources.
Three proprietary platforms have been developed: (1) MoA GALAXY™, (2) MoA TARGET™ and (3) MoA SELECT™, all powerful in their own right, but when used in combination offer the opportunity to revolutionize the early herbicide discovery process.
MoA GALAXY™ allows the simultaneous discovery of new herbicides and their modes of action. Data from the unique, proprietary, in vivo HTS platform is digitized and exploited by artificial intelligence to create a 'fingerprint'. MoA GALAXY™ can rapidly identify known and unknown modes of action associated with the new chemistries being screened at a scale, speed and cost previously unavailable.
MoA TARGET™ uses a unique in vivo plant based genomic patented process to identify the precise target protein associated with the new mode of action, which is responsible for the novel chemistry’s herbicidal activity. This predicts safety to humans and the environment, and assists in the discovery of more effective analogues for this mode of action.
MoA SELECT™ validates the mode of action and the efficacy of the test chemistries in a single in vivo assay. Active ingredients discovered by MoA SELECT™ can provide both new structurally unrelated and diverse starting points for further traditional lead optimization. This allows broad patent coverage of the new area of chemistry to be quickly and efficiently established.